Process of manufacturing iodin preparations.



UNITED I STATES MAX COHN, or BERLIN, GERMANY.

PATENI OFFICE.

PROCESS OF MANUFACTURING 'IODIN PREPARATIONS.

srnerrtearron forming part of Letters Patentll'o. 694,945, dated March 1 1, 1902.

Application filed August 17,1901.

To aZZ 20. 1.0111 it may concern.

Be it known that I, MAX COHN, a subjectof the German Emperor, residingat 21 Konigin Augusta Strasse, in the city of Berlin,

5 Kingdom of Prussia, German Empire, have invented a. certain new and useful Process for a the Manufacture of Iodin Preparations, of ivhich the following is a specification.

The strong antiseptic properties of iodoform are well known, the effect being due to the iodin separating off from this compound as soon as it comes in contact with the suppurating wound, the pus being absorbed by the preparation. The antiseptic properties [5 of iodoform are due exclusively to the iodin in a nascent state, while the undecomposed preparation has no antiseptic-properties. In

spite of this excellent quality the use of iodoform has not met with favor generally in conzo sequence of its very strong, prominent, and.

disagreeable odor. In some cases the iodoform has therefore been even replaced by other remedies of inferior therapeutic prop erties. I

This invention has reference to a process by meansof which I am enabled to manufacture an antiseptic iodin preparation in which the iodin operates similarly to the iodin contained in iodoform without possessing the nasty odor of the latter. This object is attained by combining iodin with gelatin.

I am aware that it is, old to combine iodin with tannic acid and tense such preparation as a substitute for iodid of potash. In this tannin preparation the iodin being combined with organic constituents cannot be eliminated without destroying the molecule. The preparation referred to is obtained by precipitation of glue with tannin or alcohol, re

spectively. The preparation obtained by my process, however, differs entirely fromthe old product, inasmuch as chemical combination of the iodin with the gelatin should be avoided, only a mechanical combination of the iodin with the other constituents being intended. This object of a'mechanical combination is obtained by using the drying process for the manufacture of the preparation instead of resorting to precipitation by alcohol or glue, as in the previous process.

In order to carry out my invention, I may,

alum.

Serial No. 72,361. on specimens.)

for instance, take three parts of iodid of potash and one hundred parts of gelatin and dissolve the same in one thousand parts of distilled water. Then iodin Vapors to the amount of one and one-half (1%) parts are introduced into the liquid and then some agent to harden or solidify-the preparation-such as, for instance, one per cent. of chromic After the gelatin mixture has cooled down itis dried on threads, then rasped or ground to a fine powder.

Instead of using iodin vapors the iodin may also be added in solution or as a solid to the gelatin solution, and it is obvious that instead of gelatin I may also use any superior grade of glue orjelly-li he or similar substance.

The process may be modified by replacing the water for edecting the solution of the gelatin bya decoction or infusion of camomile or lavender.

I may of course use an y desired proportions of potassium iodid, of gelatin, and of iodin, I may also make any desired additions to the new antiseptic possessing medicinal or antiseptic properties to suit various purposes.

. That the iodin is not merely mechanically mixed with the gelatin, but mechanically combined therewitlnis proven'by' the fact that the iodin in this preparation is odorless and not volatile.

The organic iodin preparations, though they have proven to be inefficient for surgical purposes, aroused with success internally as an antiseptic on account of their being relatively free from poisonous properties. On

the contrary, the preparation obtained by my invention is intended exclusively for external use,'and by this means iodin has been reduced into a pulverulent form of easy applicability and great efficiency in surgery. Its use in surgery is depending upon the iodin being contained therein in an inodorous and non-volatile form,the combination being such that by the action of moisture the iodin is liberated and rendered operative. The action of the powdered preparation follows from its quality of absorbing moisture and only splitting off iodin thereafter. Upon being applied to suppurating wounds the pus is absorbed by the powdered gelatin iodin prepa-- ration and is directly acted upon by the splitoff iodin, which latter by its strong antisephardening or solidifying the mixture, then tical properties destroys the germs and bacdrying and comminuting the same.

teria or prevents their growth. In Witness whereof I have hereunto signed What I claim, and desire tosecure by Letmy name, this 26th day of July, 1901, in the 5 ters Patent of the United States, is presence of two subscribing witnesses.

" The pFoc ess for producing iodin preparations, containing glue and possessing antiseptic properties, which consists in dissolving Witnesses:

potassium iodid and gelatin substances in WOLDEMAR HAUPT, 10 water, addingiodin to the resultantsolution, HENRY HASPER.

MAX COHN. 

